Host species: Mouse & Rat

Tropism:

• lymphoid tissue

• primary replication: GI tissue (Parvo requires rapidly dividing cells)

Clinical disease:

• unapparent

Morbidity and mortality:

• unsure, but likely 100% of susceptible animals are infected

• mortality: zero

Interference with research:

Oncology

• suppresses LGL leukemia cells in F344 rats (RPV-1) (Jacoby, 1996)

Immunology

• immunodepression and immunostimulation depending on yet undescribed factors (McKisic, 1995)

References:

McKisic MD, Paturzo FX, Smith AL. 1996. Mouse parvovirus infection potentiates rejection of tumor allographs and modulates T cell effector functions. Transplantation, 61 (2):292-299.

McKisic MD, Lancki DW, Otto G, et al. 1993. Identification and propagation of a putative immunosuppressive orphan parvovirus in cloned T cells. J. Immunol. 150:419-428.

Jacoby RO. Personal communication.

Smith AL, Jacoby RO, Johnson EA, et al. 1993. In vivo studies with an "orphan" parvovirus of mice. Lab. Animal Sci. 43:175-182.

Ball-Goodrich LJ and Johnson EA. 1994. Molecular characterization of a newly recognized mouse parvovirus. J. Virol. 68:6476-6486.

Jacoby RO, Johnson EA, Ball-Goodrich L, et al. 1995. Characterization of mouse parvovirus infection by in situ hybridization. J. Virol. (In Press)

Kimsey PB, Zhao Z and Shek WR. 1988. Immunological Characterization of Rodent Parvovirus. 39th Annual AALAS Meeting.

Legendre D and Rommelaere J. 1992. Terminal regions of the NS-1 protein of the parvovirus minute virus of mice are involved in cytotoxicity and promoter trans inhibition. J. Virol. 66:5705-5713.

McKisic MD, Paturzo FX and Smith AL. Mouse parvovirus infection potentiates rejection of tumor allografts and modulate T cell effector functions. Submitted for publication, 1995.

Ball-Goodrich LJ. Personal communication.

Riley L. 1994. Rodent orphan parvoviruses: characterization of multiple isolates and development of diagnostic assays to detect infections. 45th Annual AALAS Meeting, Pittsburgh PA.