Name: Ketoprofen

Trade Name(s): Anafen

Preparation: Anafen injection is supplied in two concentrations, 10 mg/ml for small animals and 100 mg/ml for large animals, in multidose vials. It is also available as 5mg, 10mg and 20mg tablets.

Description: Ketoprofen is a nonsteroldal anti‑inflammatory (NSAID) and analgesic drug of the propionic acid subclass of carboxylic acid derivatives. Other propionic acid derivative NSAIDS Include ibuprofen, naproxen and fenoprofen.

Availability: Ketoprofen is a prescription drug

Indications: Ketoprofen has potent anti-inflammatory activity against acute, subacute and chronic infflammation, and is useful for management of post‑surgical pain, and for relieving chronic pain (e.g., arthritis, etc.) and for the symptomatic treatment of fever.

Dosage: Consult the laboratory animal veterinarian.

Routes of administration: Ketoprofen can be injected by intramuscular, intravenous or subcutaneous routes, or given orally (tablets).

Duration of action: Ketoprofen has a long duration of action and can usually be administered once a day. Onset of activity occurs within 1/2 hour after parenteral injection and within 1 hour of oral administration.

Mechanism of analgesic action: The primary mechanism of action is through inhibition of prostaglandin synthesis by interfering with the cyclo‑oxygenase pathway of arachidonic acid metabolism.

Clinical pharmacology: Ketoprofen is propionic derivative; 2‑(3‑benzoyl phenyl) propionic acid. Other propionic acid derivative NSAIDS include ibuprofen. Like other NSAIDs, ketoprofen produces analgesic, anti‑inflammatory, and antipyretic effects.

Notes: Like other NSAIDs, ketoprofen may cause irritation of the gastrointestinal tract, and should not be used if there is impaired liver and/or kidney function, or coagulation disorders.

References:

Compendium of Veterinary Products, 6th Ed. 1999. Canadian Animal Health Institute. North American Compendiums, Hensall, Ontario

Pain Management in Animals. 2000 Flecknell P and Waterman-Pearson A (eds). WB Saunders, London 184pp.

Laboratory Animal Anesthesia. 1996. Flecknell P. Academic Press, London. 274 pp.